英语翻译In addition to their presence in the embryo,adult chimer
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英语翻译
In addition to their presence in the embryo,adult chimeras were also produced from PKO cells and some of these demonstrated the incorporation of PKO cells by their coat color.Furthermore,chimeric mice produced PKO cell-derived F1 progeny,confirmed by Nanog-GFP fluorescence of the morula.These results demonstrated that somatic cells were reprogrammed to a pluripotent status by expression of reprogramming factors Prmt5,Klf4,and Oct3/4.
In addition to their presence in the embryo,adult chimeras were also produced from PKO cells and some of these demonstrated the incorporation of PKO cells by their coat color.Furthermore,chimeric mice produced PKO cell-derived F1 progeny,confirmed by Nanog-GFP fluorescence of the morula.These results demonstrated that somatic cells were reprogrammed to a pluripotent status by expression of reprogramming factors Prmt5,Klf4,and Oct3/4.
除了存在于胚胎(期)外,(这些)成熟的嵌合体同样可由PKO细胞产生,其中一些通过其毛色还可证实PKO细胞的嵌合(状态).此外,嵌合子小鼠可孕育出由PKO细胞衍生出的F1子代,(这一点)可经桑椹胚的Nanog-GFP荧光性证实.这些(研究)结果表明,体细胞通过Prmt5, Klf4, and Oct3/4等重构因子重新编排、从而表达出多能态.
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