what happened ______ you?you look so upset.(介词填空)

what happened ______ you?you look so upset.(介词填空) You look so upset.What's wrong? You look so upset.What's wrong with you?. Do you know (是什么)made her look so upset?(what) What happened __ you You look so worried. ------What made you so upset ? -What made you so upset? You look so upset.what's wrong with you?The door ___.can you Why do you look so upset you look so upset,what's wrong with you?the door _______.Can What makes you so upset _____ what do you think( )him so upset?