英语翻译SUMMARYBoth microRNAs and alternative pre-mRNAsplicing h

来源：学生作业帮编辑：神马作文网作业帮分类：英语作业时间：2024/11/11 07:05:29

英语翻译
SUMMARY
Both microRNAs and alternative pre-mRNA
splicing have been implicated in the development
of the nervous system (NS),but functional
interactions between these two pathways are
poorly understood.We demonstrate that the
neuron-specific microRNA miR-124 directly
targets PTBP1 (PTB/hnRNP I) mRNA,which
encodes a global repressor of alternative premRNA
splicing in nonneuronal cells.Among
the targets of PTBP1 is a critical cassette
exon in the pre-mRNA of PTBP2 (nPTB/
brPTB/PTBLP),an NS-enriched PTBP1 homolog.
When this exon is skipped,PTBP2 mRNA
is subject to nonsense-mediated decay
(NMD).During neuronal differentiation,miR-
124 reduces PTBP1 levels,leading to the accumulation
of correctly spliced PTBP2 mRNA and
a dramatic increase in PTBP2 protein.These
events culminate in the transition from non-NS
to NS-specific alternative splicing patterns.
We also present evidence that miR-124 plays
a key role in the differentiation of progenitor
cells to mature neurons.Thus,miR-124 promotes
NS development,at least in part by
regulating an intricate network of NS-specific
alternative splicing

总结
　　小分子核糖核酸和替代pre-mRNA
　　拼接与疾病发展
　　神经系统(NS),但功能
　　这两个通道之间的交互
　　知之甚少.我们证明
　　特异性神经元微rna直接mir - 124
　　目标PTBP1 mRNA(PTB / hnRNP我)
　　编码一个全球premRNA阻遏的选择
　　拼接在nonneuronal细胞.在
　　盒式PTBP1的目标是至关重要的
　　外显子的pre-mRNA PTBP2(nPTB /
　　NS-e brPTB / PTBL
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